Artfully stylish, contemporary and urbane, Hyatt Regency Greenville is a luxury hotel ideally located on Main Street in downtown Greenville. Our award-winning hotel offers a refreshing blend of Southern hospitality and modern, urban convenience. Whether you are visiting for business or family vacation, our downtown Greenville, SC hotel on NOMA Square is a dynamic retreat where you can relax, dine, meet, and play. A contemporary hotel and conference center in the heart of downtown, the newly-renovated Hyatt Regency Greenville features 35,000 square feet of stylish and innovative meeting and event space in Greenville, SC. A refreshing blend of high-tech capability, urban elegance and Southern charm, our hotel offers 17 meeting rooms and venues, including our soaring glass atrium, magnificent Grand Regency Ballroom and the beautiful outdoor plaza with soothing fountains.