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The International Narcotics Research Conference 2016

Exhibition Area, sf
Exhibition Hall
Largest Ballroom, sf
Ballroom Seating
Hotels, Rooms
Jul 2016



The 2016 Meeting of the INRC will be held in the historic town of Bath, England from 10 to 14 July. This meeting will be held jointly with the British Pharmacological Society (BPS). The scientific sessions will run from Monday am to Thursday pm, with an opening welcome reception on the Sunday evening and the banquet on the Thursday evening.


United Kingdom


Fiona Marshall

Executive Vice President and Chief Scientific Officer Sosei Group June 2015 – Present (1 year) Sosei is a biopharmaceutical company originating from Japan but with global presence. Sosei's primary business model is based on identifying novel and/or differentiated product assets or technology platforms. Through supporting these in preclinical and clinical development and establishing commercial partnerships, Sosei advances new medicines to patients worldwide. Chief Scientific Officer and Founder Heptares Therapeutics 2006 – Present (10 years)Welwyn Garden City Heptares is a clinical-stage company creating novel medicines targeting G protein-coupled receptors (GPCRs), a superfamily of receptors linked to a wide range of human diseases. Our proprietary structure-based drug design platform has enabled us to build an exciting pipeline of new medicines with potential to transform the treatment of Alzheimer’s disease, ADHD, diabetes, schizophrenia, migraine, and other diseases. Our ability to address highly validated, yet historically undruggable, GPCRs has also attracted multiple partners including AstraZeneca, Cubist, Morphosys and Takeda. Heptares is a wholly owned subsidiary of Sosei Group Corporation. To learn more about Heptares, please visit (Open)4 honors and awards Visiting Lecturer University of Cambridge 2002 – 2006 (4 years)Deptartments of Pharmacology and Chemical Engineeering Lecturer to Part II undergraduate pharmacology students in Drug discovery. Module co-ordinator for 3 modules – ‘Treating Disease’, Drug Discovery and Biotherapeutics for Bioscience Enterprise Masters course. Lecturer in Genomics and Personalised Medicine to Medical students Invited lecturer in Functional genomics at University of York. Corporate Industrial advisor to University of Sheffield advising on course content and structure and academic/commercial collaborations. Independent Consultant to Venture Capital and Biotech companies F.H.Marshall Consultancy 2002 – 2006 (4 years) Independent consultant for wide range of Pharmaceutical, Biotech and Venture Capital companies. Providing strategic and scientific advice on drug discovery, pharmacology and technology. Non-executive director CellAura Member of Scientific Advisory Boards of Abingworth, Paradigm, Inpharmatica Biofocus, Oxagen, Sentinel and Merlion. Consultant to Venture Capital companies including Abingworth, Advent International, Mizuho, MVM and Cambridge Gateway. Consultant to MRC, Shire, Cancer Research Technologies, Chroma, Amura Ltd (previously Proteom), Galapagos, Biovitrum, BioImage, Novasite, Celltech, Millennium Director Biology Europe Millennium Pharmaceuticals 2000 – 2002 (2 years)Cambridge, United Kingdom Recruited to build a Drug Discovery Biology function for Millennium in Europe from scratch. The UK site was involved in Millennium’s Oncology drug discovery with an emphasis on kinase targets. Responsible for lead optimisation biology on oncology targets from HTS to clinical trials. Head of Molecular Pharmacology GSK 1998 – 2000 (2 years)Stevenage, United Kingdom The Department consisted of 75 multidisciplinary scientists who focussed on different protein classes. The Departement included units working on GPCRs, Ion channels, Integrins and Proteases. Head of Receptor Systems Unit GlaxoWellcome 1995 – 1998 (3 years)Stevenage, United Kingdom The Unit was responsible for GPCR research in GlaxoWellcome UK and had a high success rate in contributing to Drug Discovery projects. The group had a high academic profile, demonstrated by an extensive publication list including cloning of the GABAB receptor, first demonstration of GPCR heterodimerisation, cloning of the CGRP and adrenomedullin receptors, identification of the RAMP proteins, de-orphanning of GPR41, GPR43 and the nicotinic acid receptor. Team Leader Neuropharmacology Glaxo 1989 – 1994 (5 years)Ware, Hertfordshire, UK Group leader working on disease areas including epilepsy, sleep, anxiety, pain and Alzheimer’s disease.


Jul 11   

1. Opioid receptor structure and function Monday morning (July 11) Plenary: Fiona Marshall (Heptares, UK) GPCR structure, function and drug design Symposium speakers

1. Marta Filizola (Mt Sinai, New York, USA) Dynamic modelling of opioid receptors, dimers and allostery

2. Aashish Manglik (Stanford, USA) Structural insights into opioid receptor activation

3. Patrick Giguere (Ottawa, Canada) Opioid receptors – structure and bias

4. Laura Bohn (Scripps, Florida, USA) Ligand bias at opioid receptors + 3 ‘hot topics’ chosen from abstracts

2. New roles for opioids Monday afternoon (July 11) Symposium speakers

1. Lauri Nummenmaa (Turku, Finland) Opioidergic basis of human social interaction

2. Steve Husbands (Bath, UK) Novel opioid ligands: anxiety, depression (and addiction)

3. Julie Le Merrer (Tours, France) Opioids and autism

4. Charles Chavkin (Seatlle, USA) Current status of kappa-based therapies + 3 ‘hot topics’ chosen from abstracts

8.15 – 9.15          Plenary                                              

9.15 – 12.15        Symposium 1                                       

12.15 – 1.15        Lunch                                                 

1.15 – 4.15          Symposium 2                                      

4.15 – 6.45          Poster session A:                                

Datablitz 4.15 – 5                                                        

Posters 5 – 6.45                                                              


Jul 12   

3.Opioids, craving and addiction Tuesday morning (July 12) Plenary: Trevor Robbins (Cambridge, UK) Neural substrates of addiction Symposium speakers

1. Matt Hickman (Bristol, UK) Epidemiology of opioid replacement therapy

2. Alexis Bailey (St. Georges, London, UK) Oxytocin and opioid-seeking

3. Stephanie Borgland (Calgary, Canada) Orexin and dynorphin regulation of VTA circuits

4. Rafael Maldonado (Barcelona, Spain) Opioid receptors and drug-seeking behaviour + 3 ‘hot topics’ chosen from abstracts

4. Opioids: from itch to cancer Tuesday afternoon (July 12) Symposium speakers

1. Karin Loser (Munster, Germany) kappa, itch and the immune response 2. Heike Rittner (Wurzburg, Germany) Opioid-induced immunosuppression

3. Jason Boland (Hull York Medical School, UK) Opioids, the immune system and cancer

4. To be arranged + 3 ‘hot topics’ chosen from abstracts

8.15 - 9.15          Plenary

9.15 – 12.15        Symposium 3

2.15 – 1.15          Lunch

 1.15 – 4.15          Symposium 4

 4.15 – 6.45          Poster session B:

     Datablitz 4.15 – 5

Posters 5 – 6.45

Jul 13   

Opioid receptor regulation and crosstalk Wednesday morning (July 13) Founder’s Lecture: Lakshmi Devi (New York, USA) Opioid receptor regulation and dimers Symposium speakers

1. Stefan Schulz (Jena, Germany) Phosphorylation barcodes for opioid receptors

2. George Wilcox (Minnesota, USA) Functional effects of receptor crosstalk

3. Janet Lowe (Portland, USA) Agonist-induced mechanisms of mu opioid receptor regulation

4. John Traynor (Michigan, USA) Allostery at opioid receptors

5. Mac Christie (Sydney, Australia) Opioid receptor desensitization + 3 ‘hot topics’ chosen from abstracts

8.15 – 9.15          Plenary

9.30 – 12.40        Symposium 5

12.40 –               Lunch.   Including grant-writing workshop and careers workshop. Then free afternoon.

Jul 14   

Neuronal plasticity: pain and addiction Thursday morning (July 14) Plenary: Irene Tracey (Oxford, UK) Opioid human brain imaging Symposium speakers

1. Tony Dickenson (UCL, London, UK) Opioids, the spinal cord and pain

2. Anthony Jones (Manchester, UK) Pain resilience and vulnerability and the brain opioid system

3. Jose Moron-Concepcion (St Louis, USA) Opioids, synaptic plasticity and inflammatory pain

4. Jon-Kar Zubieta (Utah, USA) Mood, pain, depression + 3 ‘hot topics’ chosen from abstracts

7. Young Investigator symposium Thursday afternoon (July 14) Young Investigator: Amynah Pradhan (Chicago, USA) – to be arranged.

8.15 – 9.15          Plenary

9.30 – 12.15        Symposium 6

12.15 – 1.15        Lunch

1.15 – 4              Symposium 7

4.15 – 5              INRC Business meeting

7 – 12                 Banquet